A 'New and Improved' Cavity-Fighting Paste
By Jamie Talan <a href=www.newsday.com>News Day STAFF WRITER May 27, 2003
There is no doubt that fluoride helps fight cavities, but Stony Brook oral biologist Dr. Israel Kleinberg has developed what he believes is a better cavity- fighting substance - and he now has evidence to support his theory.
The results from a two-year study of the substance - called CaviStat - suggest that children who brushed with the bacteria-fighting substance had 96 percent fewer cavities than those who used a common fluoride paste.
"CaviStat skunked fluoride," said Kleinberg, who will present the findings next month at the International Association for Dental Research in Sweden.
Kleinberg is chairman of oral biology and pathology at the Stony Brook University and has spent his 36-year career unraveling the infectious disease process that leads to tooth decay. With 300 different types of bacteria crowding the mouth, many bacteria clump into plaque that sticks to the tooth's surface. Sugar and carbohydrates from food interact with this bacteria to form acid, which dissolves the tooth's enamel. With enamel chipping away, bacteria have room to invade the tooth. Hence, a cavity.
Decades ago, Kleinberg found in saliva a number of peptides that interact with bacteria and plaque. One peptide in particular - arginine - protects teeth from bacterial damage. It works by neutralizing acids. Kleinberg also identified another compound in saliva called precipitin that pulls together calcium and phosphate. CaviStat is part calcium builder and part bad-bacteria blocker.
"This substance shows a lot of promise," said David Pashley, a regents professor of oral biology at the Medical College of Georgia in Augusta. "The Stony Brook scientists are very rigorous in their studies."
Stony Brook partnered with scientists at Venezuela's Central University in Caracas to test the compound in a double-blind trial against fluoride. Almost 725 Venezuelan children were divided into two groups to receive either CaviStat or a fluoride toothpaste to be used three times a day. Each brushing lasted a minute, followed by a 30-second rinse.
The children who brushed with the CaviStat paste had significantly fewer cavities after the first year, and the scientists even saw a reversal of tooth decay. By the second year, the fluoride group had almost twice the number of cavities, Kleinberg said.
The study was funded by Ortek Therapeutics, a company based in Roslyn Heights that has been developing Kleinberg's findings for more than a decade.
Dental experts had hoped that fluoride, a mineral, would end tooth decay. Now that fluoride is in toothpastes and in 70 percent of the country's water supplies, cavity rates are down about 30 percent, compared with rates before fluoride's widespread use.
"We think we have something that is much better," said Kleinberg. Last year, the Food and Drug Administration approved a CaviStat polishing paste for dental offices to be used for the treatment of tooth sensitivity, a problem for millions of Americans. Now, the company is working on a paste that people can use at home for tooth sensitivity, said Mitch Goldberg of Ortek.
In time, Kleinberg says that he envisions a series of bacteria-fighting drinks, candy, gum and toothpaste designed to fight cavities.
Copyright © 2003, Newsday, Inc.
Argentines swoon over visiting Castro--Rushing crowd delays speech by two hours
The Miami Herald Posted on Tue, May. 27, 2003 BY DANIEL A. GRECH AND KEVIN G. HALL dgrech@herald.com
BUENOS AIRES - Thousands of Argentines, desperate to catch a glimpse of Cuban dictator Fidel Castro, broke through security Monday evening at the University of Buenos Aires law school, forcing organizers to postpone Castro's speech by two hours and finally move it to the steps of the law school steps.
People fainted and were trampled in the chaotic confusion. There were no reports of deaths or serious injuries, but authorities decided to evacuate the 3,200-seat hall where the speech was scheduled for security reasons.
DENOUNCED U.S.
In the end, an estimated 15,000 Argentines braved a crisp night breeze to hear Castro, the world's oldest living Communist dictator and archenemy of the United States, deliver a trademark rambling diatribe against his ``neighbor to the north.''
It was Castro's third visit to Argentina, homeland of fellow revolutionary Ernesto ''Che'' Guevara, and the first to the capital since 1959.
Castro, wearing a dark suit, was clearly impressed by the crowd spread below him waving Che banners and Cuban flags. As he took the podium at 9 p.m., Castro referred to the earlier chaos as ``an earthquake, a tidal wave, a hurricane.''
''This seems like the Plaza of the Revolution,'' Castro remarked, referring to the central square for political demonstrations in Havana. ``The organizers are guilty of underestimating the Argentine people.''
In a massive show of anti-American sentiment, the crowd chanted Bush es terrorista,'' along with the traditional
Viva Cuba'' and ``Olé Castro.''
Castro arrived in Buenos Aires Saturday for the inauguration of Argentine President Néstor Kirchner. Kirchner, a center-left politician, has called for greater ties among nations in Latin America, and he has vowed to defend jobs and industry in Argentina, which has suffered through five years of recession. Half of Argentina's 36.2 million population is at or below the poverty line.
Castro has been cheered throughout his visit, including during a meeting Monday with the new president at the Casa Rosada (Pink House), the executive office of the Argentine president.
''This is a historic moment,'' exulted Martin Tavaut, a 27-year-old lawyer, as he tried to push into the conference hall for Castro's speech. ``He is our response to the disdain we feel for the United States as a force in Latin America.''
''You want to know what we think of Fidel here?'' asked schoolteacher Graciela Dominguez, 53. ``Just take a look at this crowd.''
Castro stayed at the Four Seasons hotel with Venezuelan President Hugo Chávez. The two were greeted at the hotel by a large group of supporters.
GOOD TIMING
Castro has been a constant critic of U.S.-backed free market policies that were heartily adopted by Argentina in the 1990s. But with election of a center-left Argentine president emphasizing social justice, Castro felt the time was right to address Argentina. Although the United States has tried to isolate Cuba in Latin America, elections of left-leaning presidents in Brazil, Venezuela, Peru, Chile, Ecuador and Argentina have won Castro political support he has not enjoyed for a decade.
RECENT CRACKDOWN
Last month, Argentina abstained on a United Nations resolution condemning the Castro government for its recent execution of three hijackers and imprisonment of 75 dissidents.
The move was a reversal of previous Argentine votes against Cuba's human rights record, which prompted Castro to once taunt that Argentina was ``licking Yankee boots.''
Monday's chaos began more than an hour before Castro's speech, originally set for 7 p.m. in the school's main conference hall, when hundreds of Argentines pressed through the room's main entrances.
Students waving Cuban flags climbed onto rafters and grandmothers wearing revolutionary colors climbed onto the hall's red plush chairs before Cuban exterior minister Felipe Pérez Roque thanked the crowd for its ''militant solidarity with revolutionary Cuba'' and asked people to move outside.
''Fidel will not leave Argentina without making his speech,'' Pérez Roque promised.
US stimulus package implications
ameinfo.com Tuesday, May 27 - 2003 at 09:27
With US economic stimulus plan passed, we reiterate our preference for the pharmaceuticals and energy sectors. Our crude oil price assumptions are towards an average of USD28.50 for this year. And we have added two stocks to our recommendation list that benefit from the weak US dollar.
US equities
Congress on Friday finally passed the hotly debated economic stimulus package worth US$350bn. The centrepiece of the bill is the cut in capital gains and dividend tax to 5% and 15% from the current top rates of 38.6% and 20% for capital gains.
The bill dovetails neatly with our thematic play on stocks offering high and safe dividend yields. Our current dividend plays are Altria (MO, $42.31, CSFB: Outperform) and Carolina Group (CG, $23.66, CSFB: Not Rated). However, it is our belief that the Bill would not necessarily radically change the dividend policy of US corporations as the dividend tax cut only last through to 2009.
Insurance stocks had a pretty rough week, falling 2.96% on average vs. the S&P 500’s 1.17% decline. According to a recent report by the Insurance Services Office (ISO), property/casualty insurers are expected to pay out approximately $1.55 billion in insured losses from the severe thunderstorms and tornadoes that struck 18 states from May 2 through May 11. ISO’s Property Claims Services unit estimates that insurers will receive more than 429,000 claims from these storms.
For example, Travellers Property Casualty Corp. (TAP/A, $16.21, CSFB: Outperform) sees storm loss damages of $78 million in 2Q’03, or about $0.08 per share. All told, estimated insured losses place the storm system as the third worst windstorm event in U.S. history, behind a $2.2 billion catastrophe loss in April 2001, and a $1.7 billion catastrophe loss in April 2002. For the short-term, we remain cautious on property/casualty insurers.
Life insurers could face a negative impact from the new dividend tax policy. It appears as if dividends received in variable annuity sub-accounts will not receive the same treatment. Given the fact that variable annuities require a long holding period (roughly 12 years) for their tax advantages to overcome higher fees compared to taxable mutual funds, the new policy would erode the tax advantages that annuities have over taxable mutual funds and cause the holding period to extend to about 15 years (source: JP Morgan).
However, we do not believe this would have a significant negative impact on life insurers’ stock prices. Therefore we maintain our Buy rating on Aflac Inc. (AFL, $32.67, CSFB: Not rated). The company sells complementary insurance, helping to fill gaps in consumer’s primary insurance coverage.
Pfizer has partially recovered from the sell-off after the US Supreme Court decision that the US state of Maine can implement a program to force drug makers to extend discounts to uninsured residents from current 10% to 25%. In Maine around 325,000 people could benefit from such discounts.
The market feared that worse might happen and that this could be a precedent for other states to join in which would hurt the drug industry’s revenues.
But as further legal hurdles could prevent the implementation of this program, the worst-case scenario that the market feared, appears not to be likely at this stage. The program has still to be validated by the District Court and needs approval from the Health Secretary, which means that at this point the US Department of state determines the extent to which states are allowed to give discounts on prescription drugs.
A certain implication will be a rise in tone in the discussion about the drug price inflation and the pharmaceutical industry will be under increased pressure to contribute their part to contain the rise in prescription drug prices. This is an issue that has been on the table for years and still it seems far from conclusion, as the pharmaceutical industry has plenty of clout.
In the meantime the weakness in the share price has offered a good buying opportunity for Pfizer Inc. (PFE, $31.88, CSFB: Outperform), which with its strong growth perspectives for the next two years at least and a forecasted earnings growth of 15-18% per annum, remains a top pick in the industry.
Given the uncertainties surrounding the implementation of the Maine drug program, we estimate our valuation model for Pfizer still to be accurate and also maintain our Buy recommendation and 12-months price target of USD 37.
Our newly recommended integrated oil stock ConocoPhillips (COP, $53.16, CSFB: Outperform) had a strong week, as crude oil prices stabilized at levels above $29 per barrel West Texas Intermediate. Exxon Mobil Corp. (XOM, $35.98, CSFB: Neutral) also saw a positive share price movement. We could see prices for both stocks moving up even further, if crude oil prices stay at these levels, as analysts might have to adjust their earnings models upwards, in order to take into account higher crude oil prices.
So far our crude oil price assumptions are towards an average price of $28.50 per barrel West Texas Intermediate (WTI) for this year. But it could prove too conservative, in so far as during this year the price for the WTI has mostly traded above $28.50, peaking at $37.83 in March.
We feel comfortable with our oil price assumptions and our forecasts for ConocoPhillips and Exxon Mobil. As we had reported earlier, the supply/demand situation could tighten, if disruptions from Nigeria, Venezuela and Iraq persist into the third and fourth quarter of the year, when demand increases due to the winter season in the Northern Hemisphere.
The sector continues to have solid medium- to long-term outlook, which also explains why the two stocks have been resilient to crude oil price volatility. We therefore reiterate our buy recommendation on ConocoPhillips and Exxon Mobil.
Altria Group (MO, $41.05 CSFB: Outperform) is up nearly 18% over the past two days. Two days ago Florida's 3rd District Court of Appeals threw out a $145bn dollar punitive awards damage against the US Tobacco industry.
There are FOUR KEY IMPLICATIONS to this verdict for Altria
• The Company's and the only potential bankrupting legal threat is dead in the water • We believe the verdict should accelerate credit rating agency action with a bias to upgrade. • Altria should regain access to $1.2bn dollars it had placed in an escrow account as a bonding requirement for the duration of the appeal • The ruling should be favourable in terms of other litigation with respect to class certification
We are maintaining our target price of $46 AND raising our stop loss to $35 from 31.
European equities
• The DJ EUR Stoxx 50 closed the week 4% lower at 2246.58 • Koninklijke KPN and Adidas-Salomon added to the recommendation list. The common theme being their relative low exposure to the weakening USD.
Given the continued weak economic environment and the strengthening Euro which hit a high of 1.1832USD on Friday for the first time since the launch of the single European currency in January 1999, we are looking for companies with further cost cutting potential and with less exposure to a depreciating US Dollar.
We added two new stocks to our recommendation list: the telecom operator Koninklijke KPN (KPN NA; EUR 5.76) and Adidas-Salomon (ADS GY; EUR 74.20). The common theme for both of them is their relative low exposure to the weakening USD.
The focus of the telecom sector as a whole is more on Europe itself and therefore makes it less sensitive to EUR strengthening. In addition, KPN underperformed in the current rally as all eyes in the telecom sector were on Deutsche Telecom (DTE GR; EUR 12.12) and France Telecom (FTE FP; EUR 19.98).
We believe going forward this gap should narrow as KPN’s management is very committed to further cost cutting and their efficient operating structure should enable them to improve their competitive position. Their strategy is to focus on free cash flow and in fact KPN has one of the highest free cash flow yield in the sector. As the end demand remains weak, an investment in KPN has to be seen as a cost-cutting and restructuring story. We assigned a target price of EUR 6.50 and a stop-loss level of EUR 5.30.
Adidas has a net USD exposure of over USD 1bn (substantial part of production is outsourced to Asia denominated in USD and major part of sales is in Europe), which makes it actually a beneficiary of a depreciating USD. A
According to a study by Deutsche Bank, a 10% depreciation of the US Dollar would have a positive 20% effect on Adidas’ EBIT. Adidas has a strong brand, diversified product portfolio, low beta to the DAX and is attractively valued compared to its peers (in the last 5 years Adidas traded on a PER of 17.2x, PER for 03 stands at 13.11x; current discount to Nike 23%, which is in line with its 5-year average); current premium to Reebook 4.5% (less than its 5-year average of a 26% premium). In addition, Adidas manages to keep its margins rising on the back of an improving product mix and selective price increases. We assigned a target price of EUR 85 and a stop loss level of EUR 70.
As there are few companies, which actually benefit by a depreciating US Dollar it is also worth mentioning Arcelor (LOR FP; EUR 9.03). The positive impact of a 10% weaker US Dollar on Arcelor’s EBIT is estimated to be 10.8%. Arcelor remains a cost cutting and restructuring story as well. Created by a merger only a little over a year ago, the cost cutting achieved so far is impressive.
Besides this ‘currency theme’ we would continue to focus on defensives such as pharmaceuticals. Our favourites remain Sanofi-Synthelabo (SAN FP; EUR 51.40), Aventis (AVE FP; EUR 44.5) and Roche (ROG VX; CHF 97.7). Roche showed a particularly strong performance during the last week increasing by over 12%.
Several developments such as the successful US launch of the hepatitis C drug Pegasys, the FDA approval of the HIV drug Fuzeon, a positive FDA advisory committee vote for the anti- allergy antibody Xolair, and the announcement earlier in the week of the Phase III success of Avastin in colorectal cancer. This should lead to better visibility as the stock enjoys EPS and rating upgrades by several brokers.
Furthermore, we would continue to focus on the energy sector. According to a study by Deutsche Bank the sector with the most positive earnings revision ratio is clearly energy with upgrades for 66% of the companies.
In fact, the 2003E index earnings were upgraded by 3.2% over the last month. Other sectors with upgrades in their 2003E earnings include food & beverages, financial services and telecoms. Our favourite plays in the energy sector remain Total (FP FP; EUR 121.70) and ENI (ENI IM; EUR 13.524).
‘Zimbabwe, Guatemala y Venezuela among world’s worst economic performers’
5/27/03 3:08:31 AM (GMT +2) The Daily News-Business Reporter
THE payment of bribes to further business interests has increased in the last three years in Zimbabwe, which has been ranked 78th out of 80 countries in the World Economic Forum (WEF)’s 2002-2003 Global Competitiveness Report.
The southern African nation is ranked ahead of Venezuela and Guatamela, both facing severe economic crises.
Zimbabwe lagged far behind its closest neighbours Botswana and South Africa, who are ranked 24 and 53 respectively.
On a scale of one to seven, with one indicating a significant increase in bribery and seven a decline, Zimbabwe scored 2,4. It was slightly ahead of Venezuela, which scored 2,1 and Guatamela, with 2,0.
In terms of growth competitiveness, Zimbabwe was ranked 79 out of 80 in 2002, sliping from 75 in 2001.
“One of the worst performers (in economic competitiveness) remains Zimbabwe, where the economic downturn accelerated substantially in 2001 and 2002,” the WEF report said.
According to the report, Zimbabwe is ranked 76 out of 80 countries where companies had to make “undocumented extra payments or bribes” connected with the issuing of public contracts.
When deciding upon policies and contracts, government officials in Zimbabwe are said to favour well connected firms and individuals.
Zimbabwe government tenders for multi billion dollar projects have in the past five years been controversially awarded, resulting in some companies seeking the intervention of the courts to reverse the contracts.
Some contracts have been reversed, but as recently as 2001, crucial documents for a Japanese tender for the digitilastion of the country’s telephone network disappeared and have not been found.
According to the WEF report, Zimbabwe is also among the top five nations where insider trading is prevalent on the stock market.
However, allegations of insider trading have not been proved because of the absence of a legal framework to deal with such a practise.
Out of the 80 countries surveyed by the WEF, Zimbabwe is ranked 77, making it one of the economies where financial assets and wealth were not adequately protected by law.
South Africa is however ranked 21 and Botswana 24.
Since the invasion of mostly white-owned farms began in February 2000, foreign investors have questioned the sanctity of property rights in Zimbabwe, leading to most foreigners abandoning the country for its neighbours.
Argentina's Kirchner Meets With Regional Leaders
<a href=www.voanews.com>VOA News 26 May 2003, 22:00 UTC
New Argentine President Nestor Kirchner has met with several regional leaders, pledging to "work with everyone" to help his country overcome its severe financial crisis.
Mr. Kirchner made the promise Monday in Buenos Aires, where he spent his first full day in office meeting with the presidents of Bolivia, Cuba, Colombia, Peru, Uruguay and Venezuela.
The presidents were among several regional leaders who attended Mr. Kirchner's swearing-in ceremony on Sunday. Mr. Kirchner is Argentina's sixth president since political turmoil led to the resignation of Fernando de la Rua in late 2001.
In his inaugural address, the new Argentine leader said the country must be opened to the world. He pledged to work for conditions where Argentina can create what he called a credible and serious economy.
Mr. Kirchner also called on international markets to be patient as he works to help the economy recover from the crisis that triggered widespread unemployment and social unrest.
Argentina has defaulted on $141 billion in public debt. President Kirchner says his administration will renegotiate the debt, but warned the country cannot pay back what it owes lenders at the expense of those in need of houses, schools, and health care. Mr. Kirchner also says the priority of his new foreign policy is building a politically stable and prosperous Latin America with democracy and social justice as its foundations.